Acceptability and effectiveness of the "Education in Action-ABALL1" intervention program in primary school-aged children.

Background: Research has consistently shown the benefits of developing intervention programs in educational settings, enhancing the learning process and socioemotional skills. There is a growing investment in creating and supporting a healthy school environment, prioritizing learning through play. This study aimed to assess the acceptability and effectiveness of an innovative intervention approach-"Education in Action-ABALL1"-focused on promoting literacy and numeracy skills and socioemotional competencies of second-grade children. Methods: A total of 113 children aged between 7 and 9 participated in the study and were allocated into two groups: intervention (N = 69) and control (N = 44). The intervention consisted of 24 educational games aligned with the mathematics and Portuguese curricula, applied for 3 months, twice a week; two self-report instruments were used to measure aptitudes for school learning and socioemotional skills, considering two assessment moments: before and after the program implementation. In addition, a focus group involving a subsample of children and teachers who followed the intervention in different school cohorts was carried out. Results: Our results suggested a positive effect of the program concerning children's academic skills, showing a significant improvement in terms of the pre-post-intervention scores in the intervention group (Cohen's d = 0.95). Moreover, the qualitative findings also indicate the high acceptability of the program among children and head teachers, who reported a positive effect on the acquisition and consolidation of reading, writing, and arithmetic skills and on the promotion of teamwork, empathy, autonomy, and self-reflection. Conclusion: Overall, the "Education in Action-ABALL1" program provides a promising intervention based on learning through play directly impacting second-grade children's academic, emotional, and interpersonal skills. Further studies are required to understand the transdisciplinary capacity of this intervention approach and its effectiveness at different school levels and curricula.

Design, synthesis and biological activity of a targeted library of potential tryptase inhibitors.

We have designed, synthesized, and tested two small collections of potential tryptase inhibitors. The first library consists of diversely N-substituted 3-aminopiperidin-2-ones 6, and the second (compounds 7) was prepared by dimerising compounds 6 through the 3-amino function using diverse carbon chains. We have established efficient routes for obtaining 6 both in solution and on solid supports. We have also compared the dimerisation on-resin and in solution. Four of the compounds showed a high degree of tryptase inhibition at 1 microM, but none surpassed the tryptase inhibition activity of BABIM.

Oclusäo na odontologia estética e restauradora. Reconstruçäo estética em pacientes bruxômanos com resina composta / Occlusion in esthetics and restauration dentistry. Esthetic reconstruration of the bruxism patient with composite resin

Os autores relatam um caso clínico de paciente de 28 anos de idade com facetas de desgaste acentuado em dentes anteriores superiores, sinais e sintomas de disfunçäo oclusal (Bruxismo) e erosäo química pela ingestäo acentuada de substâncias ácidas. Este caso foi tratado com ajuste oclusal e restabelecimento da estética e guias de desoclusäo com resina composta do tipo híbrida, através do sistema de matrizes individuais do tipo "Adapta". Para proteçäo da resina e do próprio esmalte dentário foi confeccionada uma placa de proteçäo anterior de resina acrílica autopolimerizável que deve ser utilizada em períodos de maior tensäo